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Asthma Free Forever Ebook

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Asthma Free Forever Summary


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The Big Asthma Lie

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The Big Asthma Lie Summary

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Author: Max Sidorov
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Recently, a question regarding a possible role of phthalate esters in the pathogenesis of asthma has been raised 83,84 . The studies in question found phthalate esters from vinyl products in the air of households with asthmatic children. They speculated on a possible mechanism for DEHP to cause asthma. The hypothesis is that DEHP and its metabolites have some structural similarities to, and can mimic, some prostaglandins and thromboxanes, and the widespread use of DEHP in wall coverings, flooring, and other construction material leads to the induction or exacerbation of asthma. The merit of this hypothesis is questionable. There is also no direct evidence that DEHP or MEHP acts like prostaglandin, the hormone associated with inflammatory responses. Furthermore, there is no indication of any sensitization potential from exposure to DEHP, based on animal experiments or human patch tests 25 . Phthalates are not the large, complex molecules which are more commonly associated with allergy,...

Environmental health science for the next century

As part of this new approach, we must move from toxin-based regulatory control to instead focus on diseases and work backward to their causes. For example, we must make a major attack on the causes of asthma and of birth defects it will not be sufficient to control only specific pollutants that might be involved in asthma causation or exacerbation or in the development of birth defects. This risk management debate has often been conducted using political, economic, or social rhetoric. Yet the key determinant is the availability of valid and robust scientific methodology pertinent to understanding the etiology of disease. This methodology must first enable the necessary definition and surveillance of diseases caused by environmental factors. Then, it must be able to determine causes. Fortunately, the recent rapid advances in molecular biology and in other biologically relevant technologies provide the necessary tools to develop indicators of cause and effect relationships by starting...

Air pollution and health

The two gases that particularly characterize photochemical smog, O3 and nitrogen oxides, caused particular concern because of their potential to induce respiratory problems. Ozone impairs lung function, while nitrogen oxides at high concentrations are particularly likely to affect asthmatics. Oxygen-containing compounds, such as aldehydes, cause eye, nose and throat irritation, as well as headaches, during periods of smog. Eye irritation is a frequent complaint in Los Angeles and other photochemically polluted cities. This eye irritation is particularly associated with a group of nitrogen-containing organic compounds. They are produced in reactions of nitrogen oxides with various organic compounds in the smog (Box 3.6). The best known of these nitrogen-containing eye irritants is peroxyacetylnitrate, often called PAN.

Oxidative state of Cr and toxicity

Exposure to hexavalent Cr compounds has been consistently found to be associated with an elevated incidence of respiratory cancers and other adverse health effects.3-5 Squamous cell carcinoma is the most prevalent form of lung cancer among Cr(VI)-exposed workers.6 The genotoxic potential of Cr(VI) has been confirmed in animal experiments and in several cell-based assays6a7 Inhalation of Cr(VI)-containing acid mists in electroplating industry leads to nasal septum ulceration and perforation, as well as impaired lung function such as decreased vital capacity and forced expiratory vol-ume.8 Other health consequences of exposure to Cr(VI) include pulmonary fibrosis, chronic bronchitis, emphysema, and bronchial asthma.9 Ingestion of Cr(VI) can result in the irritation of mucous membranes and, in severe cases, intestinal bleeding. High doses of Cr(VI) cause renal tubular necrosis and can be lethal. Animal studies have also detected teratogenic activity of Cr(VI).9a Cr(VI) is the second most...

Potential 111 Health Effects among Compost Workers

Allergic Rhinitis and Asthma When a patient is sensitised to airborne allergens, exposure to those allergens can trigger the immunoglobulin E (IgE) pathway of the immune system causing allergic rhinitis (inflammation of the nasal passageways) or allergic asthma (upper respiratory tract broncho-constriction). Rhinitis and asthma frequently coexist in the same patient and both diseases are increasing in prevalence in the general population. Organic dust rhinitis and asthma are not caused by a single allergen present in the dust different allergens may be responsible in different patients.29'58-60 Workers handling compost are often exposed to higher levels of allergens than the general population and the species to which they are exposed may differ. studies with pure endotoxin have shown that in normal healthy subjects an inhalation of over 30-300 xg endotoxin can cause a clinical response.68 70 Inhalation of endotoxin can also result in decreases in lung function and inflammatory...

Pathways of Amines and Their Toxicity

Amines are considered to have negative environmental impacts. It was reported that occupational asthma was found in a patient handling a cutting fluid containing diethanolamine (DEA). DEA causes asthmatic airway obstruction at concentrations of 0.75 mg m3 and 1.0 mg m3 (Piipari et al. 1998). Toninello (2006) reported that the oxidation of amines appears to be carcinogenic. DEA also reversibly inhibits phosphatidylcholine synthesis by blocking choline uptake (Lehman-McKeeman and Gamsky 1999). Systemic toxicity occurs in many tissue types including the nervous system, liver, kidney, and blood system. Hartung et al. (1970) reported that inhalation by male rats of 6 ppm (25.8 mg m3) DEA vapor 8 hours day, 5 days week for 13 weeks resulted in depressed growth rates, increased lung and kidney weights, and even some mortality. Rats exposed continuously for 216 hours (nine days) to 25 ppm (108 mg m3) DEA showed increased liver and kidney weights and elevated blood urea nitrogen. Barbee and...

Populations That Are Unusually Susceptible

People with preexisting lung, kidney, or liver damage may be more at risk than the general population in the event of HCCPD exposure because of compromised organ function. Asthmatics are probably also likely to be more affected. In two studies of human exposure to HCCPD in the workplace, respiratory

Occurrence of inflammatory episodes

Acute or chronic inflammatory response. In addition, there are many diseases or conditions that are associated with tissue inflammation, among which are arthritis, hepatitis, atherosclerosis, asthma, and others. Finally, studies over the last two decades indicate that we commonly experience episodic exposure to bacterial endotoxin, a potent initiator of inflammation.

Irritation Sensitization

No evidence for a sensitization potential of the phthalate esters from animal studies. There are a few case reports describing potential skin sensitization after dermal contact with phthalate-containing products. Based on limited information of possible interference with other substances, these reports are not conclusive. In a comprehensive volunteer study with seven dialkyl (C6-C13) phthalate esters in a human-repeated, insult patch test using the modified Draize procedure, no evidence of dermal irritation or sensitization for any of the seven phthalates was observed 25 . These data suggest that phthalate esters are not likely to play a role in the induction of asthma, or other allergic or irritation-induced response (vide infra).

Sources And Types Of Air Pollution

Wood stoves contribute significantly to air pollution. This type of pollution is a potential health threat to children with asthma and elderly people with chronic lung problems. Wood stove use may have to be limited. Stoves are being redesigned to keep the air pollution at acceptable levels.

Human Challenge Studies

For a range of reasons, including availability of volunteers and ethical concerns about exposing individuals with moderate to severe disease to a potentially risky substance, most subjects used in these studies have been younger, healthy volunteers, although some studies have exposed subjects with mild asthma. Only two studies have exposed individuals with significant cardiac disease60 or chronic lung disease.61 There have been studies of DEP exposure giving adequate information on particle size distribution.62 66 Most delivered moderately high concentrations in mass terms (100-300 mg m 3). These studies broadly suggested that DEPs can cause a neutrophilic inflammatory response in both normal and asthmatic subjects, probably mediated through IL-8, with some evidence of endothelial activation especially in the asthmatic subjects. There are two reports of CAP exposures, which suggest an airway neutrophilic response perhaps with an endothelial response.67

Sulfur And The Sulfur Cycle

Sulfur Cycle

Sulfur is an important, relatively abundant, essential element. As is true of many elements, it takes part in a biogeochemical cycle discussed shortly. It is a major component of air pollution, particularly in industrialized areas, although natural sources of sulfur also contribute. Several oxidation states are encountered in environmental systems the most stable under aerobic conditions is S(VI) as in SO3 and sulfates. The reduced form S(-II) is encountered in organic sulfides, including some amino acids, in H2S, and in metallic sulfides. It is a reduction product of sulfates under anaerobic conditions. Oxidation of sulfides produces chiefly SO2 S(IV) as the immediate product. Sulfur dioxide and sulfites, the salts produced when SO2 reacts with base, are reducing agents and are used as antioxidants in some foods (e.g., cut fresh fruits and vegetables, some shellfish, wine). While sulfite is generally not considered harmful, it causes asthmatic reactions, sometimes severe, in...

Physiological Effects and Toxicity

Pentavalent Transition State

Human vanadium poisoning symptoms are mainly restricted to the conjunctivae and respiratory system, renal and gastrointestinal irritation. Exposure can thus give rise to conjunctivitis, rhinitis, pulmonary inflammation resulting in bronchitis and asthma-like diseases, and dysfunctions of the digestive system. The limit value for immediate danger to health for an average human is about 7 mg V in the case of intravenous application, and 35 mg V m-3 in breathing air. The following compilation lists selected official exposure limits (MAC) and LD50 LC50 values. MAC refers to the maximum allowable concentration at the workplace (40-h week, 8-h time-weighted average). LD50 and LC50 indicate the level of a harmful substance (in mg per kg body weight) causing the death of 50 of the test animals by oral (LD) or inhalative (LC) administration, respectively.

Harmful Effects of Chemical Disinfectants

There is wide spread potential for human exposure to disinfection byproducts (DBPs) in drinking water because everyone drinks, bathes, cooks and cleans with water. Chlorine can cause eye, nose, stomach problems and sinus irritation when ingested via drinking water. Inhalation of chlorine leads to asthma, showering of Chlorinated water can magnify the effects of chlorine inhalation, due to the enclosed nature of shower stalls.

Psychological Impacts of Oil Spills The Exxon Valdez Disaster

Because psychological stress can lead to physiological changes and increased risks for chronic diseases, Palinkas and colleagues examined the impact of the Exxon Valdez spill on physical health. As with the psychological outcomes, researchers found that more-exposed individuals reported more heart disease, high blood pressure, diabetes, thyroid problems, cancer, asthma, ulcers, bronchitis, chronic coughs, and skin rashes (Impact Assessment, Inc., 1990).

Advantages and Applications of Biogas

Reported that, in developing countries, by installing biogas plants, diseases like asthma, lung problems, and eye infections have considerably decreased in the same area when compared to the pre-biogas plant times. Salomon and Lora (2009) estimated the electricity generation potential of biogas from different sources of organic residues, viz., sugar and alcohol industry residues (vinasse), urban solid and liquid wastes (garbage and sewage) and livestock wastes (bovine and swine manure), and described the advantage of biogas production as follows the bio-digestion process can reduce the polluting potential of organic residue discharges with high contents of biochemical oxygen demand (BOD), and at the same time, it can produce methane and a fertilizer agent as residue . Biogas can be used for the generation of electricity with the help of internal combustion engines, as a fuel in substitution of natural or liquefied petroleum gas (LPG), heat generation for incubators and coolers, and as...

Multiplex phenotypes

A trait that is dependent on two or more genes is called polygenic, multifactorial, or a multiplex phenotype. Examples of a polygenic trait include height, obesity, blood pressure, coronary artery disease, asthma, diabetes mellitus, or the formation of the jaw during embryonic development. Mul

Illnesses Associated with Air Pollution Lung Diseases

The particulate and gaseous contaminants in polluted air may irritate the eyes and respiratory system or damage the clearance mechanism of the lungs, thereby increasing susceptibility to upper respiratory diseases and aggravating existing chronic illnesses. Diseases mentioned as also being associated with air pollution include bronchial asthma (restriction of the smaller airways or bronchioles and increase in mucous secretions), chronic bronchitis (excessive mucus and frequent cough), pulmonary emphysema (shortness of breath), lung cancer, heart diseases, and conjunctivitis (inflammation of the lids and coatings of the eyeballs) (also with lead and carbon monoxide poisoning as previously discussed). In an example of the built environment influencing health, one study found the higher prevalence of asthma in poor neighborhoods of Hartford, Connecticut, to be due in large part to a heavy burden of dust laden with cockroach antigen.73 Bronchial asthma affects susceptible sensitive...


Epidemiology following exposure to other particles does not help greatly. Mortality and morbidity results from studies of workers producing titanium dioxide (TiO2) were reviewed by Hext et al.55 Overall, these results are similar in nature to those for carbon black. However, nanoparticle TiO2 is a very small fraction of the overall market and the results applied particularly to coarser TiO2. Welders are exposed to very fine particles. There is a huge literature on mortality and morbidity of welders. However, the effects depend on exactly what metals are being welded and so it is difficult to extrapolate to the new nanotechnology industries. We note, however, that some of the effects may be immediate (acute). There is an extensive literature confirming excess cancer mortality (lung cancer, mesothelioma) and respiratory morbidity following occupational exposure to asbestos, as well as studies of other fibres. This may be relevant, because of the fibrous shape of some new nanomaterials....

Subject Index

Adverse birth outcomes, 103, 116 Aerated static piles, 74 Air pollutants, classical, 174 Air pollution control, 163 Allergenic fungi, 80 Allergic asthma, 84 Allergic rhinitis, 84 Alternar a spp., 84 Ambient air quality standards, 182 Ambient bioaerosol levels, 91 Arsenic, 185 Ash residues, 163 Aspergillosis, 80, 99 Aspergillus spp., 78 Aspergillus fumigatus, 79 Asthma, allergic, 84 Atmospheric dilution, 131 Atmospheric modelling, 131


Hairy roots of Hyptis capitata (knobweed), Polycarpaea longiflora and Euphorbia hirta (asthma weed or hairy spurge) were studied for their tolerance and accumulation of Cu (Nedelkoska and Doran, 2000a). Whereas the short-term (9-h) Cu uptake capacities of H. capitata and P. longiflora roots were similar, the Cu content of E. hirta roots was lower than for the other species. In longer-term culture experiments (28 days), growth of H. capitata roots was not significantly affected by 20 ppm Cu in the presence of an equimolar concentration of disodium ethylene diaminetetraacetate dihydrate (EDTA). Cu uptake by H. capitata roots was biphasic with initial rapid accumulation followed by a slower increase in Cu content.


Chromium is causally associated with mutations and malignancy (Leonard and Lauwerys 1980 Norseth 1981) . Under appropriate conditions, Cr is a human and animal carcinogenic agent its biological effects depend on chemical form, solubility, and valence. In general, Cr6+ compounds are hazardous to animals, whereas metallic Cr and Cr3+ are essentially nontoxic (Gale 1978) however, exposure to water solubi-lized Cr3+ has caused cancers and dermatitis in workers, and toxicity in rabbits (Hatherill 1981). In the chromate producing industry workers who developed respiratory cancer had been exposed to 30-1,100 mg m3 Cr in air for periods of 4-24 years, and workers producing chromate pigment who developed respiratory cancer had been subjected to an estimated Cr6+ exposure of500-1,500 mg m3 for 6-9 years. Carcinogens released in the chromate manufacturing process have not yet been identified (Post and Campbell 1980). Levels as low as 10 mg m3 of Cr6+ in air produced strong irritation in nasal...

A NAcetylation NAT2

P450 monooxygenases (oxidation deficiencies) debrisoquine (CYP2D6), S-mephenytoin (CYP2C19 & CYP2C9), nifedipine (CYP3A4), coumarin and nicotine (CYP2A6), theophylline (CYP1A2), acetaminophen (CYP2E1), CYP1A1, CYP2B6 6. b-Adrenergic receptors (ADRB1, ADRB2, ADRB3) and sensitivity to b-agonists in asthmatics


The control of b-agonists misuse received extra attention after outbreaks of food poisoning in 1990 in Spain caused by consumption of bovine liver. This was the first time that pharmacological residues found in slaughtered cattle were found to have caused acute intoxication in consumers. As therapeutic drugs, they have been first used as a bronchodilator for the treatment of pulmonary diseases in humans and animals. b-Agonists act specifically by binding to cell membrane b-receptors, and therefore, by activating the adenylate cyclase-cyclic AMP system. Physiological responses to stimulation of the b-receptors are increased lipolysis and reduced lipogenesis in adipose cells, increased glycogenolysis, increased protein synthesis and reduced proteolysis in striated muscle fibres, and vasodilatation, bronchodilatation and relaxation of smooth muscle fibres. Although clenbuterol is still probably the most popular b-agonist illegally used on farms, other b-agonists have been pointed out on...

Gas Sensors

Air pollutants have been the major factor contributing to the degradation of air quality, leading to chronic effects on human health, such as chronic obstructive pulmonary diseases, cardiovascular diseases, asthma, and cancer (Yang and Omaye 2009 Kampa and Castanas 2008). Air pollutants, such as carbon monoxide (CO), carbon dioxide (CO2 ), sulphur oxides (SOx ), nitrogen oxides (NOx ), ozone (O3 ), volatile organic compounds (VOCs), heavy metals, and particulate matter (PM2.5 and PM10) are generated from human-derived anthropogenic activities, especially combustion of fossil fuels. Noteworthy that some of these hazardous air pollutants are

Indoor Air Pollution

The levels of some common air pollutants often are greater indoors than outdoors, although pollutant concentrations do vary significantly from one building to another. Since most people spend more time indoors than outdoors, exposure to indoor air pollutants is an important environmental problem and may cause more problems to human health than does outdoor air. Indeed, the inadequate ventilation practices encountered in developing countries that burn coal, wood, crop residues, and other unprocessed biomass fuels create smoke and carbon monoxide pollution that produces respiratory problems and ill health among huge numbers of people in these countries. Women and young children are particularly affected since they spend more time indoors. Cooking smoke from biomass fuels increases asthma rates among elderly men and women. The particulate emissions from traditional cook stoves used indoors in developing countries can be reduced by 90 by switching from wood to charcoal. It is estimated...


The state has been conducting syndromic surveillance among seven hospitals in impacted areas for increases in respiratory illness or asthma. At the time of the workshop, in comparison to trends over the past 3 years, there was no indication of spill-related increases in either outcome.

Joel Tickner

While we have known for decades that many industrial chemicals are toxic, mounting evidence indicates that some of these chemicals play a role in the onset of diseases including cancer, developmental and behavioral disorders, respiratory ailments and asthma, neurological disorders, and birth defects, among others. Despite


The compost workers were found to have significantly more symptoms and diseases of the airways and skin than the control subjects. These included tracheobronchitis, mucous membrane irritation, sinusitis, eczema, dermatomycosis, pyoderma, nausea and ear inflammation. One compost worker complained of typical ODTS symptoms. Severe cases of infection or EAA or asthma were not found. Twenty compost workers had one or several increased antibody concentrations compared with only three biowaste collectors and one control. Significantly higher antibody titres to A. fumigatus were measured in workers at the composting plants. Compost workers also had higher titres to the other Upper Airway Inflammation 119 J. E. Brown, D. Masood, J. I. Couser and R. Patterson, Ann. Allergy, Asthma Immunol., 1995, 74, 44-47. The outcome of a large study on the health of a population living near to a grass and leaf composting plant at Islip, New York was recently reported.106 Sixty-three people living near the...

Systemic Effects

Clinical observations strongly suggest that Yusho and Yu-Cheng patients experienced frequent or more severe respiratory infections (Kuratsune 1989 Rogan 1989). Chronic bronchitis accompanied by persistent cough and sputum production was observed in 40-50 of some examined patients, with symptoms gradually improving during 5-10 years following onset (Nakanishi et al. 1985 Shigematsu et al. 1971, 1977). Physical findings differed from those in usual bronchitis in that many nonsmokers showed no crackles and some showed wheezes without radiologic, physiologic, or immunologic evidence of bronchial asthma or pulmonary emphysema (Nakanishi et al. 1985 Shigematsu et al. 1971). Information on immune status in Yusho and Yu-Cheng patients is discussed in Section

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