Absorption

Methylene chloride is most commonly absorbed by inhalation, however it may also be ingested accidentally or deliberately. Dermal absorption is usually low because methylene chloride rapidly evaporates, however in cases of heavy skin contamination (e.g., immersion), or if methylene chloride is trapped against the skin by gloves or clothing, then absorption may be higher and systemic toxicity may occur (ATSDR, 1993a,b). Dermal absorption of methylene chloride has been demonstrated in human volunteer studies (Stewart and Dodd, 1964).

Exposure level and duration, physical activity, smoking and body fat all affect the methylene chloride body burden (Mahmud and Kales, 1999). As much as 70% of the inhaled vapour may be absorbed via the lungs (DiVincenzo and Kaplan, 1981b). Inhalation of methylene chloride appears to result in higher carboxyhaemoglobin concentrations compared to ingestion. For example, a peak carboxyhaemoglobin concentration of 12.1% was recorded in an adult female 26 hours post ingestion of 300 ml of a paint remover containing 81% methylene chloride and 14% methanol (Hughes and Tracey, 1993). This carboxyhaemoglobin concentration is much lower than that of 50% recorded in a 20 year old female after use of a methylene chloride paint remover in a poorly ventilated room (Fagin et al., 1980). A study of human volunteers exposed to 1,000 ppm for 1 to 2 hours showed that carboxyhaemoglobin concentrations may remain elevated for 17 hours (Stewart et al., 1972a, b).

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment