n-Hexane is rapidly absorbed. Steady-state concentrations of n-hexane in blood depend on the exposure concentration. The blood concentration of n-hexane has been shown to correlate with air concentrations and alveolar air concentration (Brugnone et al., 1978). The pulmonary uptake of n-hexane in workers is 17% (Mutti et al., 1984). In an experimental study near-plateau concentrations were reached after 15 minutes of exposure (Veulemans et al., 1982).
There is limited information on dermal absorption of n-hexane. In a limited study, no n-hexane was detected in the blood or exhaled air in a volunteer who immersed one hand in n-hexane for 1 minute (Nomiyama and Nomiyama, 1975).
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