Carcinogenicity

A study of 262 men working in an isopropanol plant, for an average of 15.5 years, found that there were 26 deaths, which is slightly above the expected number (23.6). There was also a non-significant increase in deaths from neoplasms (9 against an expected 6.19). Of the deaths from cancer, only the incidence of carcinoma of the nose and sinus was above the expected level compared to the general population (Alderson and Rattan, 1980). Teta et al. (1992) also found an increased incidence of laryngeal cancer among workers involved in the process of manufacturing isopropanol and ethanol by the strong acid process. However, it is unclear whether this increased incidence is due to the isopropanol itself, some intermediary in the process in this plant, or the strong acid method.

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