Chronic exposure

Inhalation

There is limited information on the chronic effects of diisobutyl ketone. Headache, vision loss and peripheral neuropathy have been reported in a worker exposed to fumes of heated diisobutyl ketone. Results of neurological and neuropsychological evaluation suggested some affective changes with deficits in manual motor speed, verbal fluency, visuospatial organisation and short-term memory (White et al., 1993). However, there was no measurement of exposure concentrations of diisobutyl ketone or evaluation of exposure to any other chemicals in the workplace. Consequently, the cause of the neurological effects is unclear.

In rats exposed to 905 ppm for 6 hours on nine occasions there was evidence of toxicity only in males. There was an increase in kidney weights, increased urine volume, hyaline droplets in the renal tubules and increased serum proteins and liver weights. Similar, but less pronounced effects were observed at 300 ppm. The effects resolved or decreased over a 2 week recovery period. The significance of these findings to human exposure is unknown (Dodd et al., 1987).

Toxicology of Solvents Dermal

Chronic exposure to diisobutyl ketone on the skin may cause drying and cracking. Dermatitis may occur due to its defatting action (Hathaway et al., 1996).

No information available. Ingestion

No information available.

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