Chronic exposure

In most cases of chronic poisoning clinical effects resolve gradually once exposure has ceased. There is no withdrawal syndrome (Hormes et al., 1986). A chronic toluene abuser with progressive cerebellar dysfunction and visual deterioration (reduced acuity and defective colour vision) did not improve with 5 months of abstinence, but showed dramatic improvement after amantadine administration for 3 months. When amantadine was stopped his condition deteriorated. After two years of therapy he showed great improvement and had only mild dysarthria, visual acuity (6/12) and mildly impaired colour vision (Deleu and Hanssens, 2000).

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