Chronic exposure

In severe cases, monitor liver and renal function, and monitor for haemolysis. Treatment is supportive.

Toxicology of Solvents REFERENCES

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Brooks TM, Meyer AL, Hutson DH. 1988 The genetic toxicology of some hydrocarbon and oxygenated solvents. Mutagenesis 3: 227-232.

Carpenter CP, Smyth HF. 1948 Chemical burns of the rabbit cornea. Am J Ophthalmol 29:1363-1372.

Hathaway GJ, Proctor NH, Hughes JP. 1996 Proctor & Hughes' Chemical Hazards of the Workplace, fourth edition. John Wiley & Sons Inc, New York.

Keith HM. 1932 Effect of diacetone alcohol on the liver of the rat. Arch Pathol Lab Med 13:707-712.

REPROTEXT® Document. 2001 Diacetone alcohol. In: Heitland G & Hurlbut KM (editors): REPROTEXT® Database (electronic version) MICROMEDEX, Greenwood Village, Colorado, USA. Available at www.tomescps.com/DATA/RE/RE1405.HTM (site visited 24/07/01).

Silverman L, Schulte HF, First MW. 1946 Further studies on sensory response to certain industrial solvent vapors. J Ind Hyg Toxicol 28:262-266.

Smyth HF, Carpenter CP. 1948 Further experiences with the range finding test in the industrial toxicology laboratory. J Ind Hyg Toxicol 30:63-68.

Topping DC, Morgott DA, O'Donoghue JL. 2001 Ketones of six to thirteen carbons. In: Patty's Toxicology, fifth edition, Volume 6. Bingham E, Cohrssen B, Powell CH (editors). John Wiley & Sons Inc, New York.

Vezina M, Kobusch AB, du Souich P, Greselin E, Plaa GL. 1990 Potentiation of chloroform-induced hepatotoxicity by methyl isobutyl ketone and two metabolites. Can J Physiol Pharmacol 68 (8):1055-1061.

Von Oettingen WF. 1943 Aliphatic alcohols. Public Health Bull 281:138.

Von Scheele C, Althoff P, Kempi V, Schelin U. 1976 Nephrotic syndrome due to subacute glomerulonephritis - association with hydrocarbon exposure? Acta Med Scand 200:427-429.

Walton DC, Kehr EF, Loevenhart AS. 1928 A comparison of the pharmacological action of diacetone alcohol and acetone. J Pharmacol Exp Ther 33:175-183.

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