Hexane is lipophilic. Tissue/air partition coefficients for in vitro tissue samples ranged from 2.8 to 5.2 for heart, muscle, brain, kidney and liver, whereas the fat/air partition coefficient was 104 (Perbellini et al., 1985).

In a study in rats, tissue concentrations of 2,5-hexanedione were not proportional to the dose of n-hexane and the highest concentrations were found in the blood, kidneys and sciatic nerve (Baker and Rickert, 1981). n-Hexane is distributed in tissues in quantities proportional to their lipid content. The exception is the blood, which has a disproportionately high concentration (Bohlen et al., 1973). Fetal concentrations of n-hexane and the metabolites methyl n-butyl ketone and 2-5-hexanedione were similar to maternal tissue concentrations (Bus et al., 1979).

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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