Distribution

Hexane is lipophilic. Tissue/air partition coefficients for in vitro tissue samples ranged from 2.8 to 5.2 for heart, muscle, brain, kidney and liver, whereas the fat/air partition coefficient was 104 (Perbellini et al., 1985).

In a study in rats, tissue concentrations of 2,5-hexanedione were not proportional to the dose of n-hexane and the highest concentrations were found in the blood, kidneys and sciatic nerve (Baker and Rickert, 1981). n-Hexane is distributed in tissues in quantities proportional to their lipid content. The exception is the blood, which has a disproportionately high concentration (Bohlen et al., 1973). Fetal concentrations of n-hexane and the metabolites methyl n-butyl ketone and 2-5-hexanedione were similar to maternal tissue concentrations (Bus et al., 1979).

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment