Elimination

Using the data of Stewart et al. (1965) it was calculated that the carbon tetrachloride concentration in expired air appeared to decline exponentially in a biphasic manner, with an initial half-life of less than one hour, and a second phase half-life of about 40 hours (ATSDR, 1994).

In a 61 year old man who intentionally ingested approximately 250 ml of carbon tetrachloride, whole blood concentrations fell in a bi-exponential fashion. The half-life of the first phase was 10.7 hours and of the second phase 42.6 hours. Carbon tetrachloride remained detectable for eight days (Mathieson et al., 1985).

In rats, faecal elimination of unchanged carbon tetrachloride, did not significantly contribute to the overall elimination of carbon tetrachloride, either after acute treatment (intravenous or intraperitoneal) or after repeated inhalation exposures (Page and Carlson, 1994).

In monkeys, at least 51% of the absorbed dose was eliminated in the expired air as carbon tetrachloride (40%) and carbon dioxide (11%) in 29 days after exposure. Significant amounts were excreted in urine and faeces as metabolic products, including urea and carbonates (McCollister et al., 1951).

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