The concentration of exhaled n-hexane has been shown to correlate with the concentration of n-hexane in air and the urinary concentration of 2,5-hexanedione. Exposure to 176 mg/m3 (50 ppm) resulted in a urinary 2,5-hexanedione concentration of 7.2 mg/l and an exhaled n-hexane concentration of 25.4 mg/m3 (7.2 ppm) (Periago et al., 1993). It is estimated that about 10% of absorbed n-hexane is exhaled unchanged (Mutti et al., 1984). The elimination of n-hexane is rapid and biphasic with half-lives of 0.2 and 1.5-2 hours (Veulemans et al., 1982).

In a study in rats the half-life of n-hexane was 1-2 hours in all tissues except the kidney where it was 5-6 hours (Baker and Rickert, 1981). In a comparative study in the rat, rabbit and monkey subjected to inhalation of n-hexane at 5,000 ppm for 6, 12 and 24 hours, 2,5-hexanedione was still detected in the urine 60 hours following exposure. It was also found that the maximum rate of excretion of 2,5-hexanedione occurred several hours after exposure had ceased (Perbellini et al., 1982).

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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