Genotoxicity

NMP was reported to induce chromosome loss in Saccharomyces cerevisiae (Mayer et al., 1988; Zimmermann et al., 1989) at concentrations between 150 and 230 mM. The cellular target for inducing aneuploidy has not been identified. There was no increase in the induction of other nuclear genetic effects (Mayer et al., 1988). NMP was not mutagenic in the mouse lymphoma L5178Y cell line, Salmonella typhimurium (Lee et al., 1987), or in the Ames Salmonella typhimurium/microsome assay, in either the presence or absence of metabolic activation (Wells et al., 1988).

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