Genotoxicity

DMF has been well studied and appears to have no mutagenic activity (Antoine et al., 1983; Kennedy, 1986). There is limited evidence of genotoxicity in workers exposed to DMF. In vitro and in vivo tests for genotoxicity have shown that DMF does not induce damage in genetic material (IPCS, 1991; BUA, 1994). However, there are several reports of chromosome aberrations in the lymphocytes of exposed workers (Koudela and Spazier, 1979; Major et al., 1998) and this has not been adequately explained (BUA, 1994).

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