Genotoxicity

Only limited mutagenicity testing has been conducted on n-hexane (IPCS, 1991). n-Hexane has produced negative results in point mutation assays but there is some evidence that it can produce chromosomal aberrations in vitro (IPCS, 1991).

2,5-Hexanedione was a weak inducer of chromosome loss in yeast but very potent in the presence of propionitrile (Zimmerman et al., 1989). However, this test may not be suitable as a predictor of genetic damage because no direct action on genetic material occurs (Topping et al., 2001).

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