Glomerulonephritis after occupational exposure to diacetone alcohol and ethanol in paint

A 59 year old man spent 3 days painting a floor using 30 l of paint containing a mixture of diacetone alcohol and ethanol as solvents. He first noticed oedema of the legs a month later. Despite initial improvement with diuretic therapy, his oedema could not be controlled and he had gained 12 kg in weight. He was admitted to hospital where nephrotic syndrome was suspected and a renal biopsy revealed a subacute proliferative glomerulonephritis. A lasting remission was obtained with immunosuppressive therapy (Von Scheele et al., 1976). This is an isolated case report and the role of diacetone alcohol is unclear.

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