Metabolic interaction

• Chloroform

MIBK and its metabolites, 4-hydroxy-4-methyl-2-pentanone and 4-methyl-2-pentanol, can potentiate the hepatotoxicity of chloroform in animals. None of the three compounds had any hepatotoxic effects when given alone (Vezina et al., 1990). Similarly MIBK has been shown to potentiate choleostasis induced by taurolithocholate in rats. Bile flow was unchanged when the animals were exposed to MIBK alone (Plaa and Ayotte, 1985). This potentiation of hepatotoxicity is probably due to the induction of cytochrome P450 enzymes (Vezina et al., 1990).

Animal studies have shown that MIBK can increase the CNS depressant effects of ethanol. However, this is probably due to the depressant effects of MIBK and its metabolites rather than through changes in ethanol metabolism (Sharkawi et al., 1994).

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