Metabolic interactions

NMP has been shown to enhance transcutaneous penetration of both polar and non-polar substances. In in vivo mimic studies NMP significantly increased the rate and quantity permeating human skin of acetone-deposited ibuprofen, flurbiprofen and mannitol films. Following a single application of NMP the accelerant effect was transient and shown to be reversible; the drugs redeposited on the skin as the NMP was absorbed and its content in the membrane depleted (Akhter and Barry, 1985; Barry and Bennett, 1987). NMP enhanced penetration, as evidenced by increased rate of permeation, was also shown for hydrocortisone and progesterone (Barry and Bennett, 1987). In the occupational setting NMP may enhance the penetration of other dermally absorbed substances.

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