Metabolic interactions Ethanol

As ethanol is the preferred substrate of alcohol dehydrogenase (ADH), it blocks the metabolism of glycol ether, and the production of the toxic metabolites. As a result of this interaction, ethanol is used as an antidote in glycol ether poisoning. It is only useful in the immediate phase after exposure, as administration of ethanol is of very little benefit once the glycol ether has been metabolised. The drug, fomepizole, has a similar action to ethanol, and has been used as a substitute for ethanol in glycol ether intoxication (Nisse et al., 1998).

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