Metabolism

Hexane is metabolised by cytochrome P450-dependent monoxygenases and alcohol dehydrogenase in the liver to a number of metabolites including 2,5-hexanedione, 2-hexanol, 2,5-dimethylfuran, methyl n-butyl ketone (2-hexanone) and y-valerolactone. 2,5-Hexanedione (a y-diketone compound) is usually found in the greatest concentration (Perbellini et al., 1980; Governa et al., 1987) and is believed to be the substance responsible for neurotoxicity. The urinary concentration of 2,5-hexanedione has been shown to correlate with both hexane exposure (Perbellini et al., 1981a; Iwata et al., 1983; Mutti et al., 1984; Saito et al., 1991; Cardona et al., 1993; Periago et al., 1993) and the severity of electroneuromyographic changes in exposed workers (Governa et al., 1987), and is used as a biological indicator of exposure.

Other metabolites, 5-hydroxy-2-hexanone and 2,5-hexanediol are also metabolised to 2,5-hexanedione. 2-Hexanol is the main metabolite in animals, but is of only limited importance in humans (Perbellini et al., 1982; Fedtke and Bolt, 1987; Governa et al., 1987).

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment