Metabolism

The main mechanism of toluene metabolism is oxidation of the aliphatic chain. The product is benzoic acid. This is produced by oxidation of the methyl group of toluene via benzyl alcohol and benzaldehyde, involving alcohol dehydrogenase. Benzaldehyde is metabolised to benzoic acid via aldehyde dehydrogenase. Benzoic acid is further conjugated with glycine to form hippuric acid or with glucuronic acid to produce benzoyl glucuronic acid. The minor route of oxidation involves the aromatic ring with the formation of ortho-, meta-and para-cresol. Less than 1% of the absorbed toluene is metabolised by this route (De Rosa et al., 1987). The cresols are excreted in urine as glucuronide and sulphate conjugates.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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