There is limited information on methyl n-butyl ketone metabolism in humans. Metabolites are believed to be the same as those produced in animals. Methyl n-butyl ketone is metabolised by cytochrome P450-dependent monoxygenases and alcohol dehydrogenase in the liver. Metabolites include 2,5-hexanedione, 2-hexanol, 5-hydroxy-2-hexanone, 2,5-dimethylfuran and y-valerolactone (DiVincenzo et al., 1977). 2,5-Hexanedione (a y-diketone compound) is believed to be the substance responsible for neurotoxicity.

In the case of n-hexane the urinary concentration of 2,5-hexanedione has been shown to correlate with both hexane exposure (Perbellini et al., 1981; Iwata et al., 1983; Mutti et al., 1984; Saito et al., 1991; Cardona et al., 1993; Periago et al., 1993) and the severity of electroneuromyographic changes in exposed workers (Governa et al., 1987), and is used as a biological indicator of exposure. There is good correlation between the dose of methyl n-butyl ketone and the urinary concentration of 2,5-hexanedione in rats (Pilon et al., 1986).

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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