Metabolism

There is limited information on methyl n-butyl ketone metabolism in humans. Metabolites are believed to be the same as those produced in animals. Methyl n-butyl ketone is metabolised by cytochrome P450-dependent monoxygenases and alcohol dehydrogenase in the liver. Metabolites include 2,5-hexanedione, 2-hexanol, 5-hydroxy-2-hexanone, 2,5-dimethylfuran and y-valerolactone (DiVincenzo et al., 1977). 2,5-Hexanedione (a y-diketone compound) is believed to be the substance responsible for neurotoxicity.

In the case of n-hexane the urinary concentration of 2,5-hexanedione has been shown to correlate with both hexane exposure (Perbellini et al., 1981; Iwata et al., 1983; Mutti et al., 1984; Saito et al., 1991; Cardona et al., 1993; Periago et al., 1993) and the severity of electroneuromyographic changes in exposed workers (Governa et al., 1987), and is used as a biological indicator of exposure. There is good correlation between the dose of methyl n-butyl ketone and the urinary concentration of 2,5-hexanedione in rats (Pilon et al., 1986).

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment