The mechanism of NMP toxicity is not known. Both the parent compound and its metabolites may be responsible for the putative effects reported. Other succinimides, which undergo similar hydroxylation as the conversion of MSI to 2-HMSI, are known to have physiological activity and may be teratogenic (Horning et al., 1973; Mallow et al., 1980; Kuhnz et al., 1984; Akesson and Jonsson, 1997). However, NMP was reported to induce chromosome loss in Saccharomyces cerevisiae under specific conditions, whereas succinimide, a compound structurally similar to MSI, does not (Mayer et al., 1988; Zimmermann et al., 1989).
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