Parkinsonism following chronic inhalation

A 49 year old female worked for 20 years in a leather product company. After this time she continued to work at home for a further 11 years until the onset of illness. At home the working environment was unprotected and uncontrolled. She used two glues; one used daily (containing n-hexane 85.5%) and the other used twice weekly (containing n-hexane 49%, acetone 5%, ethyl acetate 9%, trichloroethylene 7% and 1,2-dichloropropane 5%). She first developed rapidly progressing disease with severe akinesia, moderate hypertonia, mild parkinsonism and tremor in May and stopped using n-hexane products in November. Fourteen months after this she was confined to a wheelchair. Treatment with levodopa initially gave a good response but became less effective after a few weeks and dyskinesias were evident. However, she responded well to apomorphine. Homovanillic acid in the cerebrospinal fluid (CSF) was reduced; this is consistent with findings in other Parkinsonian patients. Electromyelography revealed mild axonal neuropathy (Pezzoli et al., 1989). The neuropathy improved after removal from n-hexane exposure, but there was rapid progression of parkinsonism and she died five years after the onset of symptoms (Pezzoli et al., 1995).

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook

Post a comment