Reproductive toxicity

There are no reports of human reproductive or fetal abnormalities following workplace exposure to isopropanol (reviewed in IPCS, 1990 and Shepard, 2001). Rodent studies investigating the reproductive and teratogenic effects of isopropanol have demonstrated that isopropanol reduced fertility, maternal weight gain and fetal body weights, and caused fetal abnormalities (most commonly skeletal defects). The rats in these studies were exposed to concentrations ranging from 3,500 to 10,000 ppm for 7 hours a day for 19 days. These concentrations far exceed the isopropanol concentrations experienced in the workplace (Nelson et al., 1988).

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