Reproductive toxicity

In their review of data on the reproductive effects of carbon tetrachloride, Barlow and Sullivan (1982) concluded that the lack of human reproductive toxicity data makes evaluation impossible.

There is evidence that testicular and ovarian damage may be induced at toxic doses. From the limited evidence, carbon tetrachloride is not thought to be teratogenic or embryolethal in rats, but fetotoxicity may occur at maternally toxic doses (Barlow and Sullivan, 1982). Although carbon tetrachloride is lipophilic and may readily pass through the placenta to the fetus after maternal exposure (Dowty et al., 1976; ATSDR, 1992a), it does not appear to be teratogenic in either animals or humans in the early stages of pregnancy. The human fetus typically develops the mixed function oxidase enzyme system necessary for the toxic metabolism of carbon tetrachloride in the latter months of pregnancy, thus susceptibility to the adverse effects of carbon tetrachloride may depend on the developmental stage and on the duration and concentration of the exposure (ATSDR, 1992a).

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