The reproductive toxicity of n-hexane has not been sufficiently investigated and many studies are inadequate (IPCS, 1991). There is no substantial evidence of embryotoxicity or teratogenicity in rats (Bus et al., 1979; IPCS, 1991; Daughtrey et al., 1994). Testicular atrophy was noted in rats given 2,5-hexanedione in drinking water. These changes were seen before the onset of clinical signs of neuropathy (O'Donoghue et al., 1978). There are insufficient data to assess whether chronic in utero exposure can cause neuropathy (IPCS, 1991).
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