Summary

Toxicity is due to metabolites rather than carbon tetrachloride itself Acute exposure may result in rapid central nervous system depression

Carbon tetrachloride is a potent hepatotoxin which can produce potentially fatal hepatorenal damage following ingestion, inhalation or dermal exposure

Symptoms of hepatic and/or renal toxicity may be delayed in onset for several days

Sensitisation of the myocardium to catecholamines can occur and at high concentrations sudden death can occur from cardiac arrest

Administration of acetylcysteine may reduce complications of severe carbon tetrachloride exposure Carbon tetrachloride is considered a possible human carcinogen

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