Summary

• Methanol causes toxicity by ingestion, inhalation, and dermal exposure

• Initial clinical effects resemble alcohol (ethanol) intoxication

• Methanol itself is of a moderate order of toxicity; it is the metabolite, formic acid, that is responsible for its toxic effects

• Ethanol or fomepizole may be used as antidotes for methanol toxicity and act by blocking metabolism

• Methanol intoxication is characterised by CNS depression, metabolic acidosis and ocular toxicity

• There are no studies in the literature on the reproductive, carcinogenic or mutagenic effects of methanol in humans

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