Summary

• Relatively low acute toxicity; causes mild irritation and CNS depression

• Chronic exposure may result in peripheral polyneuropathy, characteristically distal, symmetrical sensiomotor polyneuropathy

• Neurotoxicity is due to the main metabolite (2,5-hexanedione, a y-diketone compound) and not methyl n-butyl ketone itself

• Insidious onset of clinical effects; there is deterioration after removal from exposure before gradual improvement

• Neurotoxicity usually has a good outcome depending on severity, but recovery may be slow

• Co-exposure to other solvents (e.g., methyl ethyl ketone) potentiates the toxicity of methyl n-butyl ketone

• There is limited information on the carcinogenicity, gentoxicity and reproductive toxicity of methyl n-butyl ketone

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