Trichloroethylene

Grainne Cullen SUMMARY

• Trichloroethylene is a CNS depressant and causes narcosis at high concentrations

• It is irritant to the eyes and skin and burns may occur after prolonged exposure

• Trichloroethylene may cause acute hepatic dysfunction, but this is only likely at concentrations sufficient to produce significant CNS depression

• Hepatic and renal dysfunction has been reported after occupational use

• Ventricular fibrillation may occur due to sensitisation of the myocardium to catecholamines

• Trichloroethylene is probably carcinogenic in humans

• There is insufficient information on the genotoxicity of trichloroethylene

• Trichloroethylene is not teratogenic

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