Neurological Effects

An industrial waste worker who accidentally splashed pure 2,4-DCP on portions of his right arm and leg, experienced a seizure within 20 minutes of the exposure, and died shortly thereafter (Kintz et al. 1992). Lumber mill workers exposed to a mixture of tetrachlorophenols (specific isomers not stated) and pentachlorophenol reported headaches more frequently than unexposed workers (Kleinman et al. 1986). Industrial hygiene observations of inadequate use of protective equipment to prevent skin...

Results

Chinese hamster ovary cells Chinese hamster V79 cells Sister chromatid exchanges and chromosomal aberrations Chromosomal - negative result + positive result + - borderline mutagen DNA deoxyribonucleic acid NS not specified 2.4.5-TCP did not increase DNA damage in mice given a single oral dose (164 mg kg) as indicated by alkaline elution of DNA from white blood cells and the liver (Kitchin and Brown 1988). 2,4,5-TCP was predominantly negative in standard S. typhimurium reversion bioassays...

Immunological and Lymphoreticular Effects

No studies were located regarding immunological and lymphoreticular effects in humans after oral exposure to any of the eight chlorophenol isomers discussed in this profile. Rats fed 50 mg kg day 2-CP for up to 16 weeks and mice fed 69 mg kg day 2-CP for 14 days showed no changes in humoral or cell-mediated immunological assays (Borzelleca et al. 1985a Exon and Koller 1983, 1985). Indices assessed in the Exon and Koller (1983, 1985) studies include antibody production, delayed type...

Biomarkers of Exposure and Effect

Currently, no specific biomarkers for chlorophenols are known. The presence of chlorophenols or their metabolites in urine is not necessarily diagnostic for chlorophenol exposure because these compounds are also detectable in urine after exposure to other pesticides (Hill et al. 1989 Karapally et al. 1973 Shafik et al. 1973) and hexachlorocyclohexanes (Engst et al. 1976 Koransky et al. 1975). Well-designed animal metabolism studies involving the kinetics of urinary chlorophenol...