Results

Chinese hamster ovary cells Chinese hamster V79 cells Sister chromatid exchanges and chromosomal aberrations Chromosomal - negative result + positive result + - borderline mutagen DNA deoxyribonucleic acid NS not specified 2.4.5-TCP did not increase DNA damage in mice given a single oral dose (164 mg kg) as indicated by alkaline elution of DNA from white blood cells and the liver (Kitchin and Brown 1988). 2,4,5-TCP was predominantly negative in standard S. typhimurium reversion bioassays...

Biomarkers of Exposure and Effect

Currently, no specific biomarkers for chlorophenols are known. The presence of chlorophenols or their metabolites in urine is not necessarily diagnostic for chlorophenol exposure because these compounds are also detectable in urine after exposure to other pesticides (Hill et al. 1989 Karapally et al. 1973 Shafik et al. 1973) and hexachlorocyclohexanes (Engst et al. 1976 Koransky et al. 1975). Well-designed animal metabolism studies involving the kinetics of urinary chlorophenol...