The AHR is a member of the bHLH/PAS subfamily of transcription factors that have been linked to development, oxygen homeostasis, and circadian rhythm.14,15 AHR is the only member of this family demonstrated to require ligand-dependent activation for heterodimerization and transcriptional activity. No endogenous ligand for AHR has been identified; however, a large group of environmental aromatic hydrocarbons and dietary indolecarbinols (e.g., ICZ) have been shown to bind and activate the AHR.16,17 TCDD, an unwanted environmental contaminant and one of the most potent AhR ligands, has been utilized as a molecular probe to study AHR-dependent signal transduction. Adverse outcomes observed in animals treated with TCDD include a wasting syndrome, tumor promotion in rodent liver and skin, immune dysfunction, and reproductive and developmental anomalies.18-20

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment