BAHRdependent gene transcription

In the presence of a ligand, AHR partners with ARNT to bind to dioxin-responsive enhancer (DRE) motifs (5'-GCGTG-3'), transcriptionally regulating a diverse set of gene encoding proteins involved in the metabolism of xenobiotics, fatty acids, and steroid hormones, and a second set of AhR-dependent genes postulated to play a role in growth regulation.1519 Two target genes, CYP1A1 and CYP1B1, have been demonstrated to metabolize the mitogen 17^-estradiol (E2)2122 to form 2-hydroxy- and 4-hydroxy-E2, respectively. To date, none of the identified AhR-regulated genes has been

Figure 25.2 Proposed model for AHR ligand-dependent control of cell proliferation and gene transcription. In the absence of ligand, AhR is part of an active cdk4 complex (not all of the proteins comprising this complex are shown in the model) facilitating the phosphorylation of Rb that in turn supports cell proliferation.32 In the presence of ligand (gray symbol), AHR partners with ARNT to enhance gene transcription.

Figure 25.2 Proposed model for AHR ligand-dependent control of cell proliferation and gene transcription. In the absence of ligand, AhR is part of an active cdk4 complex (not all of the proteins comprising this complex are shown in the model) facilitating the phosphorylation of Rb that in turn supports cell proliferation.32 In the presence of ligand (gray symbol), AHR partners with ARNT to enhance gene transcription.

conclusively linked to decreased proliferation or enhanced differentiation for a particular cell and/or tissue type.

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