Challenges in Chemical Food Contaminants and Residue Analysis

Michel W.F. Nielen and Hans J.P. Marvin

Contents 1. Introduction 2

1.1 The food chain: A global issue 3

1.2 Issues according to the Rapid Alert System for Food and Feed 4

1.3 Issues according to the feed and food industry 6

1.4 The consumer perception 6

2. Emerging Contaminants 7

2.1 Brominated flame retardants 8

2.2 Perfluorinated organic substances 8

2.3 Endocrine disruptors 9

2.4 Metal speciation 10

2.5 Alkaloid biotoxins 10

2.6 Peptide and protein growth promoters 11

2.7 Genetically modified organisms (GMO) 12

2.8 Nanoparticles 13

3. Masked Contaminants 14

4. Unknown Bioactive Contaminants 15

4.1 Bioactivity-directed identification of emerging unknown contaminants 15

4.2 Metabolomics approach to the identification of emerging unknown contaminants 17

4.3 In silico prediction approach to the identification of unknowns 17

5. Emerging Technologies 18

5.1 Omics 18

5.2 Bioassays 19

5.3 (Bio)nanotechnology 20

5.4 Ambient mass spectrometry 20

6. Validation and QA/QC Challenges 22

6.1 Biochemical or biological rapid screening assays 22

6.2 Comprehensive instrumental analysis methods 23

Comprehensive Analytical Chemistry, Volume 51 © 2008 Elsevier B.V.

ISSN: 0166-526X, DOI 10.1016/S0166-526X(08)00001-9 All rights reserved.

7. Conclusions and Future Trends

Acknowledgements

References

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