Identification of Data Needs

In humans involved with the cleanup of HCCPD at a waste water treatment plant, an exposure concentration as low as 0.009 ppm caused symptoms of eye irritation, and exposure to 19.2 ppm for only a few seconds affected respiration (Kominsky et al. 1980 Morse et al. 1979). Thus, acute human exposures are a concern when there are environmental releases of HCCPD. Single-dose exposures to HCCPD were evaluated in several animal species using all three routes of administration...

Systemic Effects

All systems appear to be vulnerable to HCCPD toxicity with the exception of the musculoskeletal and hematological systems. The musculoskeletal system has not been thoroughly evaluated in any of the studies of HCCPD toxicity. Respiratory Effects. The lungs are vulnerable to HCCPD after exposure by every route. In humans acutely exposed to concentrations of greater than 0.97 ppm (100-200 people, exact concentration not known) as the result of an industrial discharge, respiratory complaints...