Systemic Effects

No studies were located regarding respiratory, cardiovascular, gastrointestinal, hematological, musculoskeletal, hepatic, renal, dermal, ocular, or other systemic effects in humans or hematological musculoskeletal, dermal, or ocular effects in animals after oral exposure to HCCPD. Respiratory, cardiovascular, gastrointestinal, hepatic, renal, endocrine and body weight effects were observed in animals and are discussed below. The highest NOAEL values and all reliable LOAEL values for systemic...

Atsdr Minimal Risk Levels And Worksheets

The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) 42 U.S.C. 9601 et seq. , as amended by the Superfund Amendments and Reauthorization Act (SARA) Pub. L. 99-499 , requires that the Agency for Toxic Substances and Disease Registry (ATSDR) develop jointly with the U.S. Environmental Protection Agency (EPA), in order of priority, a list of hazardous substances most commonly found at facilities on the CERCLA National Priorities List (NPL) prepare toxicological...

Table 71 Regulations and Guidelines Applicable to HCCPD

Air OSHA Drinking Water Guideline Values Cancer Classification Newly promulgated PEL later vacated National Emission Standards for Hazardous Air Pollutants (NESHAPs) 54 FR 2464 OSHA 1989 58 FR 35338 OSHA 1993 Clean Air Act Amendments, Title III U.S. Congress 1990 EPA Administered Permit Program Yes National pollutant discharge elimination system (NPDES) Designation of Hazardous Substances Yes Determination of Reportable Quantities for Hazardous 10 pounds Waste...

Relevance To Public Health Overview

HCCPD is a highly volatile, reactive liquid that has entered the environment primarily as a result of its use in the manufacture of pesticides and flame-retardant chemicals. In recent years, limited use of pesticides synthesized from HCCPD has decreased the possibility of exposure to pesticide residues among most members of the population. Exposure to materials at hazardous waste sites is still possible. Some data pertaining to human exposures to HCCPD (100-200 people) come from an incident...

Identification of Data Needs

In humans involved with the cleanup of HCCPD at a waste water treatment plant, an exposure concentration as low as 0.009 ppm caused symptoms of eye irritation, and exposure to 19.2 ppm for only a few seconds affected respiration (Kominsky et al. 1980 Morse et al. 1979). Thus, acute human exposures are a concern when there are environmental releases of HCCPD. Single-dose exposures to HCCPD were evaluated in several animal species using all three routes of administration...